ÔçÆÚ×Ó¹¬¾±°©Í¨³£Ã»ÓГÃ÷ÏÔÖ¢×´”£¬Å®ÐԸ߷¢Ö×Áö³ÁĬµÄɱÊÖ¡£Òò´Ë£¬·¢ÏÖ¹¬¾±°©²»½öÒÀÀµÓÚ·ºÆðÖ¢×´£¬¸üÖØÔÚ½øÐй¬¾±°©É¸²é¡£¹¬¾±°©²¡ÒòÃ÷È·£¬·ÀÖεÄÒªº¦ÔÚÓÚ£º¶¨ÆÚ½øÐи¾¿Æ¼ì²é£¬¼°Ê±·¢ÏÖºÍÖÎÁƹ¬¾±°©Ç°²¡±ä£¬ÖÕÖ¹ÆäÏò¹¬¾±°©µÄÉú³¤¡£
Ŀǰ¹¬¾±°©É¸²éÒªÁì¾ùȱ·¦ÌØÒìÐÔ£¬ÇÒÖ÷¹ÛÐÔÇ¿,³£µ¼ÖÂÁÙ´²Â©ÕïºÍÎóÕï¡£ËùÒÔ̽Ë÷Ò»ÖÖÐµĹ¬¾±°©É¸²é»ò·ÖÁ÷ÊÖ¶ÎÊ®·ÖÐëÒª¡£DNA¼×»ù»¯ÊÇÒ»ÖÖ³£¼ûµÄ±í¹ÛÒÅ´«·½Ê½,Ëæ×ÅDNA¼×»ù»¯¼ì²â¼¼ÊõµÄÉú³¤,ÆäÔÚÖ×ÁöÕïÁÆÁìÓò·¢»ÓÔ½À´Ô½´óµÄ×÷Óá£
ͼƬÀ´Ô´£ºThe roles of m6A methylation in cervical cancer
Ò»¡¢¹¬¾±°©¼×»ù»¯
DNA ¼×»ù»¯Êdz£¼ûµÄ±í¹ÛÒÅ´«µ÷¿ØÒªÁ죬CpG µºÊdz¤¶ÈÔ¼ 1 kb µÄ¸»º¬ CpG ¶þºËÜÕËᣨ60%¡«70%£©µÄ DNA ÇøÓò£¬Í¨³£Î»ÓÚ»ùÒòµÄÆô¶¯×Ó»òµÚÒ»ÍâÏÔ×ÓÇøÓò£¬CpG µºµÄ¼×»ù»¯Óë»ùÒòµÄ³ÁĬÃÜÇÐÏà¹Ø£¬Ö×ÁöÒÖÖÆ»ùÒòÆô¶¯×ÓÇøÓò CpG µºµÄ¸ß¼×»ù»¯ÒýÆðÆäת¼³ÁĬ£¬¼ÓÈë°©Ö¢·¢ÉúºÍ½øÕ¹¹ý³Ì¡£
ͼƬÀ´Ô´£ºCell Death and Disease (2023) 14:734
½üÄêÀ´·¢ÏÖÐí¶à¼×»ù»¯»ùÒò¿É×÷Ϊ¹¬¾±°©±êÖ¾Îï,ÔÚ¹¬¾±°©É¸²é¼°·ÖÁ÷·½Ãæ¾ßÓÐÓ¦ÓÃǰ¾°,¶øÇÒ¾ßÓÐÔ¤²â¼²²¡×ª¹éµÈÓÅÊÆ,ÓÐÀûÓÚ¹¬¾±°©µÄÔçÆÚÕï¶Ï¼°ÖÎÁÆ¡£
DNA¼×»ù»¯¼ì²â¼¼Êõ¾ßÓп͹ۡ¢¸ßÖØ¸´ÐÔ¡¢ÓëÐźŷŴó¼ì²âµÈÌØÐÔ£¬ÇÒ¾ßÓÐ×Ó¹¬¾±°©Ôçɸ½Ï¸ßÌØÒìÐÔÓ뾫׼ÐÔ£¬ÊÇÒ»ÖÖÓÐDZÁ¦µÄ¹¬¾±°©É¸²éºÍ·ÖÁ÷ÊֶΡ£
ͼƬÀ´Ô´£ºCell Death and Disease (2023) 14:734
¶þ¡¢È¨Íþ¹²Ê¶
ͼƬÀ´Ô´£ºÍøÂç
¡¶À¶Æ¤Êé¡·ÖжԻùÒò¼×»ù»¯µÄÒâÒå¡¢»ùÒò¼×»ù»¯Ó빬¾±°©µÄ·¢Éú¡¢»ùÒò¼×»ù»¯ÔÚ¹¬¾±°©É¸²éÓë·ÀÖÎÖеÄÁÙ´²Ó¦ÓýøÐÐÁËÏêϸ½éÉÜ¡£
ͼƬÀ´Ô´£ºÍøÂç
ĿǰÎÒ¹ú×Ó¹¬¾±°©É¸²éÖ¸ÄÏÖеÄÒªÁìѧÖ÷ÒªÓÉϸ°ûѧ¼ì²é¡¢HPV¼ì²âºÍ´×ËáÈâÑÛÊӲ졣2021ÄêWHO¡¶×Ó¹¬¾±°©°©Ç°²¡±äɸ²éºÍÖÎÁÆÖ¸ÄÏ£¨µÚ2°æ£©¡·Ö¸³öδÀ´Ð¼¼Êõ£¬²¢¶Ô¹úÄÚ¾ßÓÐÁÙ´²Ö¤¾ÝÁ¦µÄ¼¼Êõ½øÐÐÕûÀí¡£ÆäÖÐDNA¼×»ù»¯¼ì²â¼¼Êõ¾ßÓп͹ۡ¢¸ßÖØ¸´ÐÔ¡¢ÓëÐźŷŴó¼ì²âµÈÌØÐÔ£¬ÇÒ¾ßÓÐ×Ó¹¬¾±°©Ôçɸ½Ï¸ßÌØÒìÐÔÓ뾫׼ÐÔ£¬ÊÇÒ»ÖÖÓÐDZÁ¦µÄ¹¬¾±°©É¸²éºÍ·ÖÁ÷ÊֶΡ£
ͼƬÀ´Ô´£ºÍøÂç
Èý¡¢ÄϹ¬28NGÏàÐÅÆ·ÅÆÁ¦Á¿¹¬¾±°©¼×»ù»¯¼ì²â
ÎÒÃÇÈ«ÐÂÍÆ³ö¹¬¾±°©¼×»ù»¯¼ì²â£¬·¢Ñï¹ú¼Ò¹æ·¶»¯·ÀÖξ«Éñ£¬Ñϸñ×ñÊØ¡¶À¶Æ¤Êé¡·µÄÒªÇ󹿷¶£¬Õë¶Ô¹¬¾±°©Ïà¹Ø»ùÒò½øÐÐDNA¼×»ù»¯¼ì²â£¬ºÏÀíÔ¤²â¹¬¾±°©·¢²¡·çÏÕ£¬¸¨Öú·ÀÖΡ¢¸üÈ«ÃæÖúÁ¦¹¬¾±°©É¸²é¡£
ÏîÄ¿ÓÅÊÆ
1¡¢DNA ¼×»ù»¯±êÖ¾ÎïÐÔÖÊÎȶ¨£¬¿ÉÖØ¸´ÐԸߣ¬½á¹û¸üΪ¿Í¹Û¡£
2¡¢DNA ¼×»ù»¯¼ì²âÄܹ»¼õÉÙ¶ÔÖÖÖÖÀàÐ͹¬¾±°©µÄ©ÕïÂÊ¡£
3¡¢DNA ¼×»ù»¯¼ì²â±ãÓÚ²ÉÑù¡£
ÊÊÓÃÈËȺ
? ÓмÒ×åÊ·
? ÉúÖ³µÀÒì³£³öѪ
? HPVѬȾµÈ
²Î¿¼ÎÄÏ×
[1] Singh D, Vignat J, Lorenzoni V, Eslahi M, Ginsburg O, Lauby-Secretan B, et al. Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO Global Cervical Cancer Elimination Initiative. Lancet Glob Health. 2023;11:E197–E206.
[2] Lei JY, Arroyo-Muhr LS, Lagheden C, Eklund C, Kleppe SN, Elfstrom M, et al. Human papillomavirus infection determines prognosis in cervical cancer. J Clin Oncol. 2022;40:1522.
[3] Cibula D, Potter R, Planchamp F, Avall-Lundqvist E, Fischerova D, Haie-Meder C, et al. The European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology guidelines for the management of patients with cervical cancer. Virchows Arch. 2018;473:391.